Advancements in preclinical screening methods for artemisinins during pregnancy

Preclinical screening methods in cancer

Cancer, a group of diseases of unregulated cell proliferation, is a leading cause of death worldwide. More than 80% of compounds which have shown promising effects in preclinical studies could not get through Phase II of clinical trials. Such high attrition rate is due to improper or selective use of preclinical modalities in anticancer drug screening. The various preclinical screening methods ...

Screening for toxoplasmosis during pregnancy.

Screening for Cytomegalovirus during Pregnancy

The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the a...

Screening for domestic violence during pregnancy.

Domestic violence is an international social issue and significant cause of trauma. Pregnant women are at risk for intentional trauma and pose unique challenges for care. Patients are often not truthful about the mechanism of injury and are reluctant to seek care. Prenatal and postpartum care can be adversely affected if the woman continues in the abusive relationship. A careful approach to scr...

Safety, pharmacokinetics and efficacy of artemisinins in pregnancy

Malaria in pregnancy can lead to serious maternal and fetal morbidity and mortality. Access to the most effective antimalarials in pregnancy is essential. Resistance to current therapies is high for all antimalarial therapies except artemisinins. Artemisinin-based combination therapy is current the first line of malaria treatment recommended by the WHO for children, adults and pregnant women in...